Citation: Yang Zheng, Huang Danfeng, Wen Lan, Wang Juanjuan, Wang Kehu, Hu Yulai. Tin Powder-Promoted "One-Pot" Synthesis of α-Methylene-γ-butyrolactones[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1725-1732. doi: 10.6023/cjoc201801021 shu

Tin Powder-Promoted "One-Pot" Synthesis of α-Methylene-γ-butyrolactones

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Huang Danfeng, huangdf@nwnu.edu.cn
Received Date: 15 January 2018
Revised Date: 11 March 2018
Available Online: 29 July 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21462037)the National Natural Science Foundation of China 21462037

Figures(2)

An one-pot reaction of various isatin compounds or α-keto esters and ethyl 2-(bromomethyl)acrylate promoted by tin powder has been investigated, affording the corresponding isatin-derived spirocyclic α-methylene-γ-butyrolactones or γ, γ-disubstituted α-methylene-γ-butyrolactones in high yields. The method uses the combination of tin powder and ethyl 2-(bromomethyl)acrylate to replace the corresponding toxic stannanes and allows the operation much easier.
- one-pot,
- tin powder,
- isatin,
- 2-(bromomethyl)acrylate,
- α-methylene-γ-butyrolactone,
- spirooxindole-γ-butyrolactone
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