Citation: Yu Wenquan, Song Lina, Tian Xianhai, Zhao Ting, Wang Manman, Wu Jie, Qiao Yan, Chang Junbiao. Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I₂-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines[J]. Chinese Journal of Organic Chemistry, ;2018, 38(6): 1530-1537. doi: 10.6023/cjoc201712045 shu

Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I₂-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines

Yu Wenquan ^a,, ,
Song Lina ^a ,
Tian Xianhai ^a ,
Zhao Ting ^a ,
Wang Manman ^a ,
Wu Jie ^a ,
Qiao Yan ^b ,
Chang Junbiao ^a,,

a.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
b.
School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001

Corresponding author: Yu Wenquan, wenquan_yu@zzu.edu.cn Chang Junbiao, changjunbiao@zzu.edu.cn
Received Date: 31 December 2017
Revised Date: 11 January 2018
Available Online: 6 June 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 81330075) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004)the National Natural Science Foundation of China 81330075the Outstanding Young Talent Research Fund of Zhengzhou University 1521316004

Figures(1)

Employing molecular iodine as the sole oxidant, a new and transition metal-free diamination reaction of α, β-unsaturated ketones with 2-aminopyridines has been developed. It can not only produce 3-acyl imidazo[1, 2-a]pyridines but can also generate novel 2-acyl derivatives regioselectively by changing the solvent and substituents in the 2-aminopyridine substrates.
- molecular iodine,
- transition metal-free,
- diamination,
- imidazo[1, 2-a]pyridine,
- regioselective
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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I2-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines

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Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I₂-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines