Citation: Yan Yingkun, Xu Qiao, Gao Yang, Liu Hui, Tang Xiaorong. Synthesis and Study on Insecticidal Activity of New Heterocyclic Chalcone Derivatives[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1763-1771. doi: 10.6023/cjoc201712027 shu

Synthesis and Study on Insecticidal Activity of New Heterocyclic Chalcone Derivatives

Yan Yingkun ^a ,
Xu Qiao ^b ,
Gao Yang ^a ,
Liu Hui ^a ,
Tang Xiaorong ^a,,

a.
School of Science, Xinhua University, Chengdu 610039
b.
School of Food and Bioengineering, Xihua University, Chengdu 610039

Corresponding author: Tang Xiaorong,
Received Date: 19 December 2017
Revised Date: 31 January 2018
Available Online: 16 July 2018

Figures(1)

Twenty one new heterocyclic chalcone derivatives were synthesized by the Claisen-Schmidt condensation and ammonolysis of acyl chloride using heterocyclic aldehyde and amino substituted acetophenone as well as acyl chloride as raw materials. The laboratorial bioassay of the insecticidal activity of the synthesized compounds was performed using Aphis craccivora and Pieris rapae as targets. The results showed that most of them had significant insecticidal activity against the two pests. Among them, the median lethal concentration (LC₅₀) of compound 2l was 1.6 μg/mL against Aphis craccivora, whose insecticidal efficacy was superior to imidacloprid with LC₅₀ of 1.8 μg/mL. The insecticidal efficacy of 1b, 1f, 2j and 2n was also close to imidacloprid against Aphis craccivora. The LC₅₀ values of compounds 1f and 2m against Aphis craccivora and Pieris rapae were 6.6 μg/mL and 8.5 μg/mL, respectively and their insecticidal activity exceeded β-cypermethrin, whose LC₅₀ was 9.2 μg/mL.
- heterocyclic chalcone,
- insecticidal activity,
- Aphis craccivora,
- Pieris rapae
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