Citation: Shao Wei, Liu Xin, Wang Tingting, Hu Xiao-Yu. Applications of Supramolecular Amphiphilc for the Construction of Drug Delivery Systems[J]. Chinese Journal of Organic Chemistry, ;2018, 38(5): 1107-1118. doi: 10.6023/cjoc201711027 shu

Applications of Supramolecular Amphiphilc for the Construction of Drug Delivery Systems

Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chmeical Engineering, Nanjing University, Nanjing 210023

Corresponding author: Hu Xiao-Yu, huxy@nju.edu.cn
Received Date: 17 November 2017
Revised Date: 4 December 2017
Available Online: 8 May 2017
Fund Project: the National Natural Science Foundation of China 21572101Project supported by the National Natural Science Foundation of China (No. 21572101)

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Stimuli-responsive supramolecular drug delivery systems (SDDSs) self-assembled by supra-amphiphiles have received tremendous attentions in cancer therapy due to various advantages of SDDSs, such as enhanced drug bioavailability, prolonged blood circulation and retention time, improved drug stability and so on. The construction of smart supramolecular drug delivery systems based on the different structural characteristics of macrocyclic compounds are reviewed and their recent applications in anti-cancer drug delivery are described. Advantages and drawbacks of the current supramolecular drug delivery systems are also discussed, along with the opportunities and challenges in future.
- supra-amphiphile,
- macrocycles,
- nanocarrier,
- drug delivery system
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