Citation: Gao Ge, Wang Ping, Liu Peng, Zhang Weihong, Mo Liping, Zhang Zhanhui. Deep Eutectic Solvent Catalyzed One-Pot Synthesis of 4, 7-Dihydro-1H-pyrazolo[3, 4-b]pyridine-5-carbonitriles[J]. Chinese Journal of Organic Chemistry, ;2018, 38(4): 846-854. doi: 10.6023/cjoc201711014 shu

Deep Eutectic Solvent Catalyzed One-Pot Synthesis of 4, 7-Dihydro-1H-pyrazolo[3, 4-b]pyridine-5-carbonitriles

Gao Ge ^a ,
Wang Ping ^b ,
Liu Peng ^a ,
Zhang Weihong ^a ,
Mo Liping ^a ,
Zhang Zhanhui ^a,,

a.
National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024
b.
Department of Chemical and Environmental Engineering, Hebei Chemical and Pharmaceutical Vocational Technology College, Shijiazhuang 050026

Corresponding author: Zhang Zhanhui, zhanhui@hebtu.edu.cn; orgsynchem@sina.com.cn
Received Date: 8 November 2017
Revised Date: 5 December 2017
Available Online: 15 April 2017
Fund Project: the Natural Science Foundation of Hebei Province B2015205182Project supported by the National Natural Science Foundation of China 21272053Project supported by the National Natural Science Foundation of China (No. 21272053) and the Natural Science Foundation of Hebei Province (No. B2015205182)

Figures(4)

Deep eutectic solvent based on L-proline and oxalic acid has been demonstrated for the first time as an efficient catalyst for synthesis of 4, 7-dihydro-1H-pyrazolo[3, 4-b] pyridine-5-carbonitrile derivatives via one-pot three-component reaction of aldehyde, 3-oxopropanenitrile and 1H-pyrazol-5-amine. The key features of this approach include the broad substrate scope, operational simplicity, recyclable catalyst and possibility to scale up giving multigram quantities.
- deep eutectic solvent,
- multicomponent reaction,
- 4, 7-dihydro-1H-pyrazolo[3, 4-b] pyridine-5-carbonitrile,
- green chemistry
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