Citation: Xiao Zhen, Yue Qiang, Ran Ziyao, Zhang Qian, Li Dong. Copper-Promoted N-Arylation of 8-Acylaminoquinoline Compounds[J]. Chinese Journal of Organic Chemistry, ;2018, 38(5): 1193-1198. doi: 10.6023/cjoc201710035 shu

Copper-Promoted N-Arylation of 8-Acylaminoquinoline Compounds

Xiao Zhen ^a,b ,
Yue Qiang ^a,b ,
Ran Ziyao ^a,b ,
Zhang Qian ^a,b,, ,
Li Dong ^b,,

a.
Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy, Wuhan 430068
b.
College of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068

Corresponding author: Zhang Qian, zhangqian620@hotmail.com Li Dong, dongli@mail.hbut.edu.cn
Received Date: 27 October 2017
Revised Date: 23 December 2017
Available Online: 10 May 2018
Fund Project: the Open Fund of Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy HBSKFQN2016003Project supported by the National Natural Science Foundation of China (No. 21702054) and the Open Fund of Hubei Collaborative Innovation Center for High-efficiency Utilization of Solar Energy (No. HBSKFQN2016003)the National Natural Science Foundation of China 21702054

Figures(2)

A copper-promoted N-arylation of 8-acylaminoquinolines has been developed. The N-arylation of 8-acylaminoquinoline with triaryl bismuth generated the target products in moderate to high yields under 40 mol% Cu(OAc)₂, 2.0 equiv. of NaHCO₃ in 1, 4-dioxane at 100 ℃ for 12 h. The reaction is compatible with a wide range of quinoline substrates, which provides a new method for synthesis of N-arylamide compounds.
- copper,
- arylation,
- 8-acylaminoquinoline,
- triaryl bismuth
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