Citation: Chen Zhen, Guo Kang, Chen Rongshun, Gu Chen, Zhou Huating, Zhu Yingguang. Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides[J]. Chinese Journal of Organic Chemistry, ;2018, 38(4): 963-968. doi: 10.6023/cjoc201710027 shu

Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides

Chen Zhen ^a ,
Guo Kang ^b ,
Chen Rongshun ^b,, ,
Gu Chen ^b ,
Zhou Huating ^b ,
Zhu Yingguang ^a,,

a.
School of Chemistry and Pharmaceutical Engineering, Taishan Medical University, Tai'an 271016
b.
Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095

Corresponding author: Chen Rongshun, rongshunchen@njau.edu.cn Zhu Yingguang, ygzhu@njau.edu.cn
Received Date: 23 October 2017
Revised Date: 1 December 2017
Available Online: 8 April 2017
Fund Project: the National Natural Science Foundation of China 21502096the Natural Science Foundation of Jiangsu Province BK20150652Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20150652), the National Natural Science Foundation of China (No. 21502096), the Fundamental Research Funds for the Central Universities (No. KJQN201629), and "333 High Level Talent Project" of Jiangsu Provincethe Fundamental Research Funds for the Central Universities KJQN201629

Figures(2)

A mild and highly efficient reductive coupling of α-bromoketones with sulfonyl chlorides is described. Various β-ketosulfones can be obtained under mild conditions in good to excellent yields. This method provides a simple and practical access to β-ketosulfones and is amenable to gram scale with no special precautions to exclude air or moisture.
- β-ketosulfones,
- α-bromoketones,
- sulfonyl chlorides,
- reductive coupling,
- manganese
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