Citation: Sun Kai, Sun Xingwen, Lin Guoqiang. Synthesis of β-Amino Carbonyl Compounds and Its Application: Total Synthesis of (+)-Sedridine[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 131-137. doi: 10.6023/cjoc201710022 shu

Synthesis of β-Amino Carbonyl Compounds and Its Application: Total Synthesis of (+)-Sedridine

Sun Kai ^a ,
Sun Xingwen ^a,, ,
Lin Guoqiang ^a,b

a.
Department of Chemistry, Fudan University, Shanghai 200433
b.
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Sun Xingwen, sunxingwen@fudan.edu.cn
Received Date: 20 October 2017
Revised Date: 31 October 2017
Available Online: 3 January 2017
Fund Project: the National Natural Science Foundation of China 20802009Project supported by the National Natural Science Foundation of China (No. 20802009)

Figures(2)

β-Amino-carbonyl fragments are important structures of many bioactive molecules and pharmaceuticals and critical synthetic blocks which can be easily converted into other structures and compounds. A novel method for preparing β-amino-carbonyl compounds with oxygen as an oxidant, palladium acetate and cuprous chloride as catalysts was reported. The chiral high allyl amine compounds can be converted into corresponding β-amino carbonyl compounds with moderate to good yield, good substrate scope, and tolerance of chiral centers. Natural product (+)-sedridine was synthesized with 32% yield.
- β-amino carbonyl compound,
- chiral high allyl amine,
- Wacker reaction,
- (+)-sedridine
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