Citation: Jing Lia, Jin Huia, Guan Meib, Wu Xiaohuaa, Wang Qiantaoa, Wu Yonga. Metal-Free Oxidation of Thiols by N-Fluorobenzenesulfonimide: A Rapid and Efficient Method to Synthesize Disulfides[J]. Chinese Journal of Organic Chemistry, ;2018, 38(3): 692-697. doi: 10.6023/cjoc201709039 shu

Metal-Free Oxidation of Thiols by N-Fluorobenzenesulfonimide: A Rapid and Efficient Method to Synthesize Disulfides

Jing Lia ^a,† ,
Jin Huia ^a,† ,
Guan Meib ^b ,
Wu Xiaohuaa ^a ,
Wang Qiantaoa ^a,, ,
Wu Yonga ^a,,

a.
Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 61004
b.
West China Hospital, Sichuan University, Chengdu 610041

Corresponding author: Wang Qiantaoa, qwang@scu.edu.cn Wu Yonga, wyong@scu.edu.cn
Received Date: 22 September 2017
Revised Date: 30 October 2017
Available Online: 15 March 2017
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 81373259, 81573286)the National Natural Science Foundation of China 81573286the National Natural Science Foundation of China 81373259

Figures(2)

A simple and rapid method is developed for the oxidation of thiols to the corresponding disulfides using N-fluorobenzenesulfonimide (NFSI) as the oxidant without any contamination by over oxidation. The synthetic protocol for disulfide bond formation proceeded efficiently under external base-and metal-free conditions with the advantages of simple operation, mild reaction conditions as well as short reaction times.
- N-fluorobenzenesulfonimide,
- oxidation,
- disulfide
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