Citation: Lin Wei, Hu Xiuxiu, Wang Yazhen, Song Shuai, Zhang Mengye, Shi Daqing. Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction[J]. Chinese Journal of Organic Chemistry, ;2018, 38(4): 855-862. doi: 10.6023/cjoc201709033 shu

Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

Lin Wei ^a,, ,
Hu Xiuxiu ^a ,
Wang Yazhen ^a ,
Song Shuai ^a ,
Zhang Mengye ^b ,
Shi Daqing ^b,,

a.
School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001
b.
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Corresponding author: Lin Wei, linwei@jsut.edu.cn Shi Daqing, dqshi@suda.edu.cn
Received Date: 21 September 2017
Revised Date: 9 November 2017
Available Online: 1 April 2017
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21502074), the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006) and the College Students Practice Innovation Training Plan of Jiangsu Province (No. 201711463010Z)Project supported by the National Natural Science Foundation of China 21502074the College Students Practice Innovation Training Plan of Jiangsu Province 201711463010Zthe Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions 15KJA150006

Figures(1)

The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. In this article, an synthetic procedure for multi-substituted indole derivatives was successfully developed by a three-component reaction of phenylglyoxal monohydrate, aromatic amine and 4-hydroxycoumarin with a catalytic amount of trifluoroacetic acid under microwave irradiation conditions. This method has the advantages of simple operation, readily available raw materials, and high atom utilization.
- indole,
- synthesis,
- three-component reaction,
- microwave
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