Citation: Zhang Tao, Wang Qiang. [Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives[J]. Chinese Journal of Organic Chemistry, ;2018, 38(2): 498-503. doi: 10.6023/cjoc201709019 shu

[Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives

Zhang Tao ,
Wang Qiang ^,

College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000

Corresponding author: Wang Qiang, wangqiang@hpu.edu.cn
Received Date: 13 September 2017
Revised Date: 17 October 2017
Available Online: 3 March 2017
Fund Project: Project supported by the Natural Science Research Program from Education Department of Henan Province (No. 14A150048)the Natural Science Research Program from Education Department of Henan Province 14A150048

Figures(2)

A novel approach for the synthesis of nicotinate derivatives has been developed by using Lewis acidic ionic liquid[Bmim]ZnBr₃, which acts as dual solvent-catalyst in promoting the tandem reaction of enaminoester and allenic ketones. In the reaction process, no catalysts or other organic solvents are used, and[Bmim]ZnBr₃ can be readily reused for three times without noticeable decrease in the catalytic activity after simple treatment. Furthermore, our method offers several advantages such as short reaction times, simple work-up procedure, environment-friendly solvent and good yields. The current methodology could also be conveniently applied to the synthesis of natural products and complex therapeutic agents occurring niacin frameworks.
- ionic liquid,
- enaminoester,
- allenic ketone,
- nicotinate
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[Bmim]ZnBr3-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives

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通讯作者: 陈斌, bchen63@163.com

[Bmim]ZnBr₃-Promoted Tandem Reaction of Enaminoester and Allenic Ketones for the Synthesis of Substituted Nicotinate Derivatives