Citation: Hui Renjie, Zhang Shiwei, Tan Zheng, Wu Xiaopei, Feng Bainian. Research Progress of Trifluoromethylation with Sodium Trifluoromethanesulfinate[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3060-3075. doi: 10.6023/cjoc201709011 shu

Research Progress of Trifluoromethylation with Sodium Trifluoromethanesulfinate

School of Pharmaceutical Science, Jiangnan University, Wuxi 214122

Corresponding author: Feng Bainian, fengbainian@jiangnan.edu.cn
Received Date: 8 September 2017
Revised Date: 9 November 2017
Available Online: 8 December 2017
Fund Project: Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20140136) and the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (No. PPZY2015B146)the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions PPZY2015B146the Natural Science Foundation of Jiangsu Province BK20140136

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Trifluoromethyl can increase the chemical and metabolic stability of drugs, improve its lipophilicity and bioavailability, and furthermore, enhance drug binding selectivities. Sodium trifluoromethanesulfinate (CF₃SO₂Na) is a stable inexpensive reagent, which has been widely used in the field of organic fluorine chemistry. The recent progress (2014~2017) in trifluoromethylation by employing CF₃SO₂Na as the trifluoromethyl source is summarized. In addition, the reactions of bifunctionalization, trifluoromethylation of aromatics, trifluoromethylthioization and other types of reactions are described respectively, with their applications and reaction mechanism. It is hoped that this review can be referred to in the studies of trifluoromethyl introduction.
- sodium trifluoromethanesulfinate,
- trifluoromethylation,
- mechanism
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