Citation: Wang Mincan. Enantioselective Analysis: Logic of Chiral Ligand Design for Asymmetric Addition of Diethylzinc to Benzaldehyde[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 162-170. doi: 10.6023/cjoc201708066 shu

Enantioselective Analysis: Logic of Chiral Ligand Design for Asymmetric Addition of Diethylzinc to Benzaldehyde

Wang Mincan ^,

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052

Corresponding author: Wang Mincan, wangmincan@zzu.edu.cn
Received Date: 31 August 2017
Revised Date: 11 September 2017
Available Online: 24 January 2017
Fund Project: Project supported by the National Natural Sciences Foundation of China (Nos. 21272216, 20972140)the National Natural Sciences Foundation of China 20972140the National Natural Sciences Foundation of China 21272216

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A detailed logic-guided approach towards chiral ligands design is described via the enantioselective analysis of the dynamic conformational behaviors of catalyst, which is based on a mathematical relationship between conformations and enantioselectivity, for asymmetric addition of diethylzinc to benzaldehyde. Following this logic thought, 94 examples, almost all highly enantioselective β-aminoalcohol ligands reported, can be rationally devised by the logic control of the dynamic conformational behaviors of the catalyst from the simplest β-aminoalcohol with one single chiral center as starting point.
- enantioselective analysis,
- conformational control,
- rational design,
- chiral ligand,
- diethylzinc
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