Citation: Wang Shan, Yan Feng, Wang Liansheng, Zhu Lei. Recent Advances in Directing Group-Induced C-H Activation Reactions[J]. Chinese Journal of Organic Chemistry, ;2018, 38(2): 291-303. doi: 10.6023/cjoc201708055 shu

Recent Advances in Directing Group-Induced C-H Activation Reactions

Wang Shan ^a ,
Yan Feng ^a ,
Wang Liansheng ^a,, ,
Zhu Lei ^a,b,,

a.
School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000
b.
Hubei Collaborative Innovation Center for Biomass Conversion and Utilization, Xiaogan 432000

Corresponding author: Wang Liansheng, wangls@hbeu.edu.cn Zhu Lei, lei.zhu@hbeu.edu.cn
Received Date: 26 August 2017
Revised Date: 21 September 2017
Available Online: 24 February 2017
Fund Project: the National Natural Science Foundation of China 21774029Project supported by the National Natural Science Foundation of China (Nos. 21774029, 21304032) and the Natural Science Foundation of Hubei Province (Nos. 2016CFB104, 2015CFC772)the Natural Science Foundation of Hubei Province 2016CFB104the National Natural Science Foundation of China 21304032the Natural Science Foundation of Hubei Province 2015CFC772

Figures(27)

C-H bonds are widely existed in almost all the organic compounds. Transition-metal-catalyzed C-H functionalizations usually have high reaction efficiency and high atom-economy. However, traditional strategies based on such transition-metal catalyzed C-H activations generally result in poor selectivities, because C-H bonds in one molecule facilely display similar reactivity. It is difficult to be utilized in preparation of natural products, pharmaceuticals and biomolecules. However, directing group can induce the metal to activate proximal C-H bonds via cyclometallated intermediates, improve the regioselectivity of the transformations. Therefore, it is extremely significant to deveplop auxiliary-induced C-H bonds activations. The research progress of directing group-induced C-H activation reactions and mechanisms for recent ten years are sumarized.
- C-H activation,
- regioselectivity,
- directing group,
- transition-metal
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