Citation: Dai Hong, Yao Wei, Sun Siyu, Li Ling, Shi Lei, Qian Hongwei, Li Chunjian, Shi Jian, Shi Yujun. Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group[J]. Chinese Journal of Organic Chemistry, ;2017, 37(12): 3155-3162. doi: 10.6023/cjoc201708020 shu

Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group

Dai Hong ^a ,
Yao Wei ^a ,
Sun Siyu ^a ,
Li Ling ^a ,
Shi Lei ^a,, ,
Qian Hongwei ^a ,
Li Chunjian ^b ,
Shi Jian ^b ,
Shi Yujun ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
Analysis and Testing Center, Nantong University, Nantong 226019

Corresponding author: Shi Lei, gaohbhe2015@aliyun.com Shi Yujun, yjshi2015@163.com
Received Date: 10 August 2017
Revised Date: 5 September 2017
Available Online: 19 December 2017
Fund Project: the National Natural Science Foundation of China 21372135the Postgraduate Research and Practice Innovation Program of Jiangsu Province SJCX17_0640the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640)

Figures(3)

In order to find novel pyrazole oxime ethers with good bioactivities, a series of novel pyrazole oxime ether compounds containing substituted pyrazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were characterized by ¹H NMR, ¹³C NMR, and elemental analysis. Preliminary bioassay displayed that most target compounds had good insecticidal activities. At the concentration of 500 μg/mL, sixteen compounds showed insecticidal activity against Oriental armyworm with 80%~100%, fourteen compounds exhibited insecticidal activity against Aphis medicaginis with 80%~100%, and twelve compounds showed insecticidal activity against Nilaparvata lugens with 70%~100%. When the dosage was lowered to 100 μg/mL, five compounds still possessed inhibitory effect against Aphis medicaginis with 50%~80%.
- pyrazole,
- pyrazole oxime,
- synthesis,
- bioactivity
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