Citation: Zhang Qianqian, Ding Qunshan, Song Chuanjun, Chang Junbiao. Asymmetric Synthesis of Methyl N-(tert-Butoxycarbonyl)indoline-2-carboxylates[J]. Chinese Journal of Organic Chemistry, ;2018, 38(1): 221-227. doi: 10.6023/cjoc201708002 shu

Asymmetric Synthesis of Methyl N-(tert-Butoxycarbonyl)indoline-2-carboxylates

a.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
b.
Collaborative Innovation Centre of New Drug Research and Safety Evaluation of Henan Province, Zhengzhou 450001

Corresponding author: Song Chuanjun, chjsong@zzu.edu.cn Chang Junbiao, changjunbiao@zzu.edu.c
Received Date: 1 August 2017
Revised Date: 31 August 2017
Available Online: 8 January 2017
Fund Project: Project supported by the Natural Science Foundation of China (Nos. 81330075, 21172202)the Natural Science Foundation of China 81330075the Natural Science Foundation of China 21172202

Figures(3)

As a characteristic structural motif of numerous biologically active natural products and new drugs, chiral indoline derivatives have attracted much attention of chemists. Although many methods are available, there is still great need to develop a new, simple and highly efficient asymmetric synthetic method of indoline derivatives. Starting from Williams chiral auxiliary, a variety of methyl (R)-N-(tert-butoxycarbonyl)indoline-2-carboxylates were obtained with high overall yields and enantioselectivity through nucleophilic substitution, intramolecular Buchwald-Hartwig coupling reaction, etc.
- indoline-2-carboxylate,
- Williams chiral auxiliary,
- Buchwald-Hartig coupling,
- asymmetric synthesis
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