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Citation: Zhao Xia, Li Tianjiao, Tian Miaomiao, Su Zhiyang, Wei Aoqi, Lu Kui. Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride[J]. Chinese Journal of Organic Chemistry, ;2018, 38(3): 677-683. doi: 10.6023/cjoc201706038 shu

Triphenylphosphine Mediated Direct Trifluoromethylthiolation of Indolizine and Pyrrole by Trifluoromethanesulfonyl Chloride

Zhao Xia ^a,, ,
Li Tianjiao ^a ,
Tian Miaomiao ^a ,
Su Zhiyang ^a ,
Wei Aoqi ^a ,
Lu Kui ^b

a.
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, Key laboratory of Inorganic-organic Hybrid Functional Material Chemistry, Ministry of Education, College of Chemistry, Tianjin Normal University, Tianjin 300387
b.
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Tianjin University of Science & Technology, Tianjin 300457

Corresponding author: Zhao Xia, hxxyzhx@mail.tjnu.edu.cn
Received Date: 28 June 2017
Revised Date: 30 September 2017
Available Online: 15 March 2017
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21572158)the National Natural Science Foundation of China 21572158

Figures(3)

A triphenylphosphine mediated direct trifluoromethylthiolation of indolizine and pyrrole by trifluoromethanesulfonyl chloride was developed. The readily accessable reagents and transition metal-free reaction conditions allowed this protocol applicable for large scales synthesis.
- trifluoromethylthiolation,
- indolizine,
- pyrrole,
- trifluoromethanesulfonyl chloride,
- triphenylphosphine
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