Citation: Xu Kuo, Feng Ziming, Yang Ya'nan, Jiang Jianshuang, Zhang Peicheng. Two New Compounds from Rhizomes of Atractylodes lancea[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 3019-3023. doi: 10.6023/cjoc201706031 shu

Two New Compounds from Rhizomes of Atractylodes lancea

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050

Corresponding author: Zhang Peicheng, pczhang@imm.ac.cn
Received Date: 23 June 2017
Revised Date: 27 July 2017
Available Online: 16 November 2017
Fund Project: Project supported by the Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences (CAMS) (No. 2016-I2M-1-010)the Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences (CAMS) 2016-I2M-1-010

Figures(4)

In our phytochemical investigations on the 80% EtOH extract of the rhizomes of Atractylodes lancea, two new compounds named (10R, 11R, 12R)-tridecane-2E, 8E-diene-4, 6-diyne-1, 10, 11, 12, 13-pentol-10-O-β-D-glucopyranoside (1) and isoscopoletin 6-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2) were isolated using various column chromatographic methods. Their planar structures were elucidated by means of spectroscopic and spectrometric analyses (UV, IR, 1D and 2D NMR, and HR-ESIMS). The relative configurational assignment of 1 was deduced by visualized Newman projections in association with the 1D NOESY spectra, whereas its absolute configuration was established by comparison of experimental electronic circular dichroism (ECD) spectra with known compounds. These results will benefit subsequent stereochemical studies of those open-chain polyhydric alcohols. Compounds 1 and 2 showed weak inhibitory effects on α-glucosidases and protein tyrosine phosphates 1B (PTP1B) at a concentration of 10 μmol·L^-1.
- Atractylodes lancea,
- 4, 6-diyne,
- polyacetylene,
- coumarin,
- absolute configuration
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