Citation: Lu Bowei, Meng Shuxian, Feng Yaqing. Progress of Fluorescent Bio-probe Based on Water-Soluble Boron-dipyrromethene[J]. Chinese Journal of Organic Chemistry, ;2018, 38(2): 350-362. doi: 10.6023/cjoc201706018 shu

Progress of Fluorescent Bio-probe Based on Water-Soluble Boron-dipyrromethene

Lu Bowei ^a,b ,
Meng Shuxian ^a,, ,
Feng Yaqing ^a,b,,

a.
School of Chemical Engineering, Tianjin University, Tianjin 300072
b.
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072

Corresponding author: Meng Shuxian, msxmail@tju.edu.cn Feng Yaqing, yqfeng@tju.edu.cn
Received Date: 15 June 2017
Revised Date: 11 September 2017
Available Online: 11 February 2017
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21676187)the National Natural Science Foundation of China 21676187

Figures(2)

Recently, the fluorescent bio-probe based on water-soluble boron-dipyrromethene (BODIPY) obtains enormous progress on structural optimization and functional modification, and becomes novel high-performance biological imaging materials owing to the development of hydrophilic modification. Focusing on the methods for improving the hydrophilicity of BODIPY, the water-soluble BODIPYs have been classified as ionic probe, electrically-neutral probe and amphiphilic probe. The research progress on the application of water-soluble BODIPY dyes in field of biology and medicine since 2006 has been summarized in this review, such as detection of necessary and pathogenicbiological chemical components, early detection and intervention of cancer, labelling drug delivery, marking specific organelles, real-time monitoring of biochemical and property changes with cells, andphotodynamic therapy. The merits of methods for improving the hydrophilicity and main issues of current studies have been summed up. The hypothesis for future directions has also been put forward.
- boron-dipyrromethene (BODIPY),
- fluorescent bio-probe,
- water-soluble,
- biological imaging
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