Citation: Wang Baoqu, Kong Lingbin, Luo Qin, Lin Jun, Yan Shengjiao. One-Step Synthesis of Isoquinolinone Compounds[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2972-2977. doi: 10.6023/cjoc201705038 shu

One-Step Synthesis of Isoquinolinone Compounds

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091

Corresponding author: Lin Jun, linjun@ynu.edu.cn Yan Shengjiao, yansj@ynu.edu.cn
Received Date: 27 May 2017
Revised Date: 6 July 2017
Available Online: 18 November 2017
Fund Project: the National Natural Science Foundation of China U1202221the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University XT412003the Natural Science Foundation of Yunnan Province 2017FA003the National Natural Science Foundation of China 21262042the National Natural Science Foundation of China 21662042the National Natural Science Foundation of China 21362042Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University (No. XT412003)the Talent Found in Yunnan Province 2012HB001

Figures(2)

A concise and efficiently route for the synthesis of isoquinolinones via one-step reaction of nitro substituted methyl 2-fluorobenzoate 1 and heterocyclic ketone aminals (HKAs, 2) in 1, 4-dioxane catalyzed by Cs₂CO₃ under reflux conditions has been developed. Isoquinolinones 3 were obtained by one-step strategy. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.
- environment friendly,
- atom economy,
- heterocyclic ketone aminals,
- isoquinolinones
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