Citation: Li Xiaobao, Chen Guangying, Shao Taiminga, Song Xiaoping, Han Changri, Yu Zhangxin. Clerodane Diterpenes from the Roots of Polyalthia laui[J]. Chinese Journal of Organic Chemistry, ;2017, 37(10): 2763-2766. doi: 10.6023/cjoc201705035 shu

Clerodane Diterpenes from the Roots of Polyalthia laui

a.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
b.
Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126

Corresponding author: Han Changri, hchr116@126.com
Received Date: 23 May 2017
Revised Date: 10 June 2017
Available Online: 23 October 2017
Fund Project: the Hainan Provincal Natural Science Foundation of Innovatie Research Team Project 2016CXTD007the National Natural Science Foundation of China 21362009the Natural Science Foundation of Hainan Province 20162031the National Natural Science Foundation of China 81360478the National Natural Science Foundation of China 81160391Project supported by the National Natural Science Foundation of China (Nos.81160391, 21362009, 81360478), the International S & T Cooperation Program of China (No.2014DFA40850), the Program for Innovative Research Team in University (No.IRT-16R19), the Hainan Provincal Natural Science Foundation of Innovatie Research Team Project (No.2016CXTD007) and the Natural Science Foundation of Hainan Province (No.20162031)the Program for Innovative Research Team in University IRT-16R19the International S & T Cooperation Program of China 2014DFA40850

Figures(3)

Five clerodane diterpenes were isolated from the roots of Polyalthia laui during a systematic phytochemical investigation. Their structures were elucidated by the NMR and HRMS data as methyl (4→2)-abeo-2, 13-diformyl-cleroda-2, 12E-dien-15-ate (1), (E)-ent-cleroda-3, 12-diene-15, 16-dioic acid (2), 14, 15-dinorclerod-3-ene-2, 13-dione (3), solidagolactone (4), and 16-hydroxy-3, 13Z-kolavadien-16, 15-olide (5). Among them, compounds 1~2 are new clerodane diterpenes. Biological evaluation of compounds 1~5 against human Hela, A549, MCF-7 and HL-60 human cancer cell lines showed that all com-pounds displayed moderate cytotoxicities against various human cancer cell lines with IC₅₀ ranged from 13.22 to 37.16 μmol/L.
- Polyalthia laui,
- clerodane diterpenes,
- cytotoxicities
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