Citation: Nie Biao, Jin Chuanfei, Zhong Wenhe, Ren Qingyun, Zhang Yingjun, Zhang Ji. Application and Recent Progress of Phosphoramidate Prodrugs Strategies and ProTide Technology in Drug Discovery[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2818-2840. doi: 10.6023/cjoc201705022 shu

Application and Recent Progress of Phosphoramidate Prodrugs Strategies and ProTide Technology in Drug Discovery

Nie Biao ^a ,
Jin Chuanfei ^a ,
Zhong Wenhe ^a ,
Ren Qingyun ^a ,
Zhang Yingjun ^a,b ,
Zhang Ji ^a,b,,

a.
State Key Laboratory of Anti-infective Drug Development, Dongguan 523871
b.
HEC Pharm Group, HEC R&D Center, Dongguan 523871

Corresponding author: Zhang Ji, zhangji@hecpharm.com
Received Date: 16 May 2017
Revised Date: 20 June 2017
Available Online: 14 November 2017
Fund Project: Project supported by the Introduction of Innovative R&D Team Program of Guangdong Province (No. 201301Y0105381261) and the State Key Laboratory of Anti-Infective Drug Development (Sunshine Lake Pharma Co. Ltd) (No. 2015DQ780357)the Introduction of Innovative R&D Team Program of Guangdong Province 201301Y0105381261the State Key Laboratory of Anti-Infective Drug Development (Sunshine Lake Pharma Co. Ltd) 2015DQ780357

Figures(41)

This review provides the brief history for the development and advances of ProTide strategies in the field of antiviral and anticancer pharmaceutical development. A summary is provided for the synthesis of nucleoside phosphoramidates, recent breakthroughs in the stereoselective assembly of chiral prodrugs and its application. This technology is extremely useful and has simplified innovative drug design of phosphorous-containing prodrugs. Simplifying such structural modification may create a new avenue of competition in the invention of new medicines from the parent drug.
- phosphoramidates,
- prodrugs,
- nucleoside and nucleotide,
- antiviral drug,
- phosphate and phosphonate,
- ProTide
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沈阳化工大学材料科学与工程学院沈阳 110142