Citation: Zhou Quanlong, Zhu Changlei, Wu Ge, Zhang Yuanfei, Zhang Min, Su Weiping. Construction of Carbazoles by Palladium-Catalyzed Direct Cross-Coupling of Indoles with in situ Generated Aryl Vinyl Ketones[J]. Chinese Journal of Organic Chemistry, ;2017, 37(10): 2655-2662. doi: 10.6023/cjoc201705014 shu

Construction of Carbazoles by Palladium-Catalyzed Direct Cross-Coupling of Indoles with in situ Generated Aryl Vinyl Ketones

Zhou Quanlong ^a,b,† ,
Zhu Changlei ^a,† ,
Wu Ge ^a ,
Zhang Yuanfei ^a ,
Zhang Min ^a,, ,
Su Weiping ^a,b,,

a.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002
b.
College of Materials Science and Engineering, Fujian Normal University, Fuzhou 350007

Corresponding author: Zhang Min, zhangmin@fjirsm.ac.cn Su Weiping, wpsu@fjirsm.ac.cn

^†

Received Date: 8 May 2017
Revised Date: 6 July 2017
Available Online: 11 October 2017
Fund Project: the National Natural Science Foundation of China 21431008the National Natural Science Foundation of China 21602221the National Natural Science Foundation of China 21332001Project supported by the National Natural Science Foundation of China (Nos. 21431008, 21332001, 21602221, u1505242)the National Natural Science Foundation of China u1505242

Figures(2)

The synthesis of carbazoles via Pd-catalyzed direct cross-coupling of indoles with in situ generated aryl vinyl ketones by using statured ketones as the olefins source is described. This protocol obviates the need for additional preparation steps of aryl vinyl ketones and therefore opens up a new door to synthesis of carbazoles in an atom-and step-economical fashion.
- palladium-catalyzed,
- dehydrogenation,
- carbazoles,
- C—H functionalization,
- cross-coupling
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