Citation: Zhang Jiayong, Abudukeremu Munira, Miao Zhiwei. Research Progress of Organophosphine-Catalyzed Annulation Reaction of Electron-Deficient Alkynoates or Ynones[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2859-2872. doi: 10.6023/cjoc201705011 shu

Research Progress of Organophosphine-Catalyzed Annulation Reaction of Electron-Deficient Alkynoates or Ynones

a.
College of Chemistry and Environmental Sciences, Kashgar University, Kashgar 844006
b.
College of Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: Abudukeremu Munira, Miao Zhiwei, miaozhiwei@nankai.edu.cn
Received Date: 7 May 2017
Revised Date: 28 June 2017
Available Online: 7 November 2017
Fund Project: Project supported by the Committee of Science and Technology of Xinjiang (No. 2016D01A016)the Committee of Science and Technology of Xinjiang 2016D01A016

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Organophosphine catalyst is a kind of strong nucleophilic Lewis base. It is widely used in the field of organic synthesis. An active and important zwitterion intermediate can be generated via nucleophilic addition of the tertiary phosphine to electron-deficient alkynoates or ynones and achieves further transformation, including isomerization, α-, β-, γ-addition reactions and [2+2], [3+2], [4+2] cycloaddition reactions. Varieties of pharmaceuticals, natural products and other bioactive moleculars could be efficiently synthesized through organophosphine-catalyzed cycloaddition reaction. The research of organ-ophosphine-catalyzed cycloaddition reaction of electron-deficient alkynoates or ynones has gained more attention. The recent development of organophosphine-catalyzed cycloaddition reaction of electron-deficient alkynoates or ynones is summarized.
- tertiary organophosphine-catalyzed reaction,
- electron-deficient alkynoates (ynones),
- cycloaddition reaction
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