Citation: Li Jun, Huang Danfeng, Zhang Huaiyuan, Zhang Xinghu, Wang Juanjuan, Wang Ke-Hu, Su Yingpeng, Hu Yulai. Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction[J]. Chinese Journal of Organic Chemistry, ;2017, 37(11): 2985-2992. doi: 10.6023/cjoc201703050 shu

Indium-Promoted Preparation of α-Methylene-γ-trifluoromethyl-γ-lactams via One-Pot Reaction

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Huang Danfeng, huangdf@nwnu.edu.cn Hu Yulai, huyl@nwnu.edu.cn
Received Date: 30 March 2017
Revised Date: 3 July 2017
Available Online: 14 November 2017
Fund Project: the National Natural Science Foundation of China 21462037Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21462037)the National Natural Science Foundation of China 21662030

Figures(1)

An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and ethyl 2-(bromomethyl)acrylate promoted by indium powder has been investigated and a series of α-methylene-γ-trifluoromethyl-γ-lactams were obtained with high yieds. The features of this process include readily available starting materials as trifluoromethyl source, mild conditions and easy operation. The reaction provides a new method for the snythesis of trifluoromethylated α-methylene-γ-lactams.
- one-pot,
- indium powder,
- trifluoroacetaldehyde methyl hemiacetal,
- trifluoroketone,
- 2-(bromomethyl) acrylate,
- arylacylhydrazine,
- α-methylene-γ-trifluoromethyl-γ-lactams
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