Citation: Jiang Kai, Cao Liang, Hao Zhifeng, Chen Meiyan, Cheng Jieluan, Li Xiao, Xiao Ping, Chen Liang, Wang Zhaoyang. Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes[J]. Chinese Journal of Organic Chemistry, ;2017, 37(9): 2221-2236. doi: 10.6023/cjoc201703041 shu

Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes

Jiang Kai ^a ,
Cao Liang ^a ,
Hao Zhifeng ^b,, ,
Chen Meiyan ^a ,
Cheng Jieluan ^a ,
Li Xiao ^a ,
Xiao Ping ^a ,
Chen Liang ^a ,
Wang Zhaoyang ^a,,

a.
School of Chemistry and Environment, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, South China Normal University, Guangzhou 510006
b.
School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006

Corresponding author: Hao Zhifeng, haozhifeng3377@163.com Wang Zhaoyang, wangzy@scnu.edu.cn
Received Date: 24 March 2017
Revised Date: 14 May 2017
Available Online: 24 September 2017
Fund Project: Project supported by the Guangzhou Science and Technology Project Scientific Special (No. 201607010251), the Applied Science and Technology Research and Development Special Foundation of Guangdong Province (No. 2016B090930004), the Undergraduates Innovation Project of South China Normal University (No. 20161415), the Natural Science Foundation of Guangdong Province (No. 2014A030313429) and the Guangdong Provincial Science and Technology Project (No. 2017A010103016)the Natural Science Foundation of Guangdong Province 2014A030313429the Applied Science and Technology Research and Development Special Foundation of Guangdong Province 2016B090930004the Guangdong Provincial Science and Technology Project 2017A010103016the Undergraduates Innovation Project of South China Normal University 20161415the Guangzhou Science and Technology Project Scientific Special 201607010251

Figures(37)

Benzothiazole group is of characteristic fluorescence, and each also contains two heteroatoms (N and S). Hence, benzothiazole group is always viewed as fluorophore and recognition moiety in structure of fluorescent probes, playing an essential role on provision of fluorescence signal and binding sites. Recently, utilizing these properties of benzothiazole moiety to design and synthesize better fluorescent probes has gradually become one of focuses in fluorescent detection research. Classifying benzothiazole-based fluorescent probes into four main categories according to different analytes, such as metal cations, anions, sulfur-containing compounds and other species, the design, synthesis, detecting mechanism and relevant application of these probes are reviewed. And their development tendency in the future is prospected.
- benzothiazole,
- fluorescent probe,
- design and synthesis,
- detecting application,
- progress
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