Citation: Yu Jiangfan, Feng Ruokun, Yang Zhen. Synthetic Studies toward Neopeltolide:A Potent Anti-cancer Natural Product[J]. Chinese Journal of Organic Chemistry, ;2017, 37(10): 2526-2543. doi: 10.6023/cjoc201703017 shu

Synthetic Studies toward Neopeltolide:A Potent Anti-cancer Natural Product

Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Department of Chemistry, Shaoxing University, Shaoxing, Zhejiang Province 312000

Corresponding author: Yang Zhen, yangzhen09@usx.edu.cn
Received Date: 8 March 2017
Revised Date: 7 June 2017
Available Online: 16 October 2017
Fund Project: the National Natural Science Foundation of China 21302129Project supported by the National Natural Science Foundation of China (No. 21302129) and the Natural Science Foundation of Zhejiang Province (No. LQ13B020002).the Natural Science Foundation of Zhejiang Province LQ13B020002

Figures(27)

(+)-Neopeltolide was isolated from a deep-water sponge of the family neopeltidae. Due to its attractive novel structure and highly potent anticancer activity, more than twenty total and formal syntheses have been reported in last decade. Herein, the synthetic studies toward the total and formal syntheses of neopeltolide are reviewed according to the synthetic strategies toward the macrolactone core.
- (+)-neopeltolide,
- macrolactone,
- anti-cancer,
- macrolactonization,
- prins cyclization,
- olefin metathesis
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