Citation: Zhou Wen-Jun, Zhang Yihan, Cao Guangmei, Liu Huidong, Yu Da-Gang. Palladium-Catalyzed Radical-Type Transformations of Alkyl Halides[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1322-1337. doi: 10.6023/cjoc201702051 shu

Palladium-Catalyzed Radical-Type Transformations of Alkyl Halides

Zhou Wen-Jun ^a,b,*,, ,
Zhang Yihan ^b ,
Cao Guangmei ^b ,
Liu Huidong ^b ,
Yu Da-Gang ^b,*,,

a.
College of Chemistry and Chemical Engineering, Neijiang Normal University, Neijiang 641112
b.
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064

Corresponding author: Zhou Wen-Jun, chemzhwj@126.com Yu Da-Gang, dgyu@scu.edu.cn
Received Date: 28 February 2017
Revised Date: 5 May 2017

Fund Project: the National Program on Key Basic Research Project of China 973 Programthe National Program on Key Basic Research Project of China 2015CB856600

Figures(18)

Palladium-catalyzed cross-coupling reactions have been developed for decades as useful methods in organic synthesis. Compared to aryl and alkenyl halides, alkyl halides are more challenging to be applied in cross-coupling reactions. This mainly arises from the difficulty in oxidative addition of alkyl halides to palladium catalyst, sluggish reductive elimination and competitive side reactions, such as β-H elimination and protonation, of the resulting alkylpalladium intermediates. These challenges have partly been overcome with the significant development of novel palladium catalysis involving single election transfer. A variety of cross couplings of alkyl halides have been developed. In this review the recent palladium-catalyzed radical alkylation using alkyl halides with the order of different types of coupling partners is summarized.
- palladium catalysis,
- alkyl halide,
- free radical
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