Citation: Wu Fang, Zhang Wenjing, An Dongli, Li Yanyun, Gao Jingxing. Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster[J]. Chinese Journal of Organic Chemistry, ;2017, 37(5): 1295-1299. doi: 10.6023/cjoc201702043 shu

Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster

National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Corresponding author: Li Yanyun, yanyunli@xmu.edu.cn
Received Date: 27 February 2017
Revised Date: 1 April 2017

Fund Project: Project supported by the National Natural Science Foundation of China 21673190and the Fundamental Research Funds for the Central Universities 20720150040Project supported by the National Natural Science Foundation of China 21173176

Figures(1)

As one of the most abundant metals on earth, iron is cheap and low toxicity. Herein we reported the asymmetric transfer hydrogenation of (ATH) ketones catalyzed by the system generated in situ from chiral multidentate aminophosphine ligand (R, R, R, R)-PN₄H₆ and Fe₃(CO)₁₂. The effects of temperature and additive on the ATH of propiophenone were examined. After optimizing the reaction conditions, we applied the catalytic system to the ATH of various aromatic ketones, obtaining the corresponding optical active alcohols with high enantioselectivities (up to 96% ee).
- chiral aminophosphine ligand,
- iron cluster,
- cheap metal,
- ketones,
- asymmetric transfer hydrogenation
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