Citation: Jiang Haifang, Zhang Min, Zhang Li, Chen Yali, Zhu Ning, Song Liping, Deng Hongmei. Synthesis of 3, 4-Diaryl-5-aryloxymethyl Isoxazole Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(9): 2399-2408. doi: 10.6023/cjoc201702026 shu

Synthesis of 3, 4-Diaryl-5-aryloxymethyl Isoxazole Derivatives

Jiang Haifang ^a ,
Zhang Min ^a,, ,
Zhang Li ^a ,
Chen Yali ^a ,
Zhu Ning ^a,, ,
Song Liping ^a,b ,
Deng Hongmei ^c

a.
Department of Chemistry, School of Science, Shanghai University, Shanghai 200444
b.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
c.
Laboratory for Microstructures, Shanghai University, Shanghai 200444

Corresponding author: Zhang Min, mzhang@shu.edu.cn Zhu Ning, lpsong@shu.edu.cn
Received Date: 20 February 2017
Revised Date: 7 April 2017
Available Online: 24 September 2017
Fund Project: the National Natural Science Foundation of China 21272153Project supported by the National Natural Science Foundation of China (No. 21272153)

Figures(2)

Due to isoxazole derivatives possess a wide range of herbicidal, insecticidal and pharmacological activitives, the synthetic methodologies for preparation of isoxazole derivatives have drawn much attention in recent years. Herein, 3, 4-diaryl-5-aryloxymethyl isoxazole derivatives were effectively synthesized from 3-aryl-5-(bromomethyl)isoxazole via consecutive bromination, etherification, followed by Suzuki coupling reaction catalyzed by Pd(PPh₃)₂Cl₂. Preliminary bioassay data showed that some of the title compounds exhibited certain insecticidal activities against Oriental armyworm.
- isoxazole derivatives,
- bromination,
- etherification,
- suzuki coupling reaction
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