Citation: Chen Lin, Wang Qian, Huang Shuai, Shan Lianhai, Gao Feng, Zhou Xianli. Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1839-1843. doi: 10.6023/cjoc201702021 shu

Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity

Chen Lin ^a,b,c ,
Wang Qian ^a ,
Huang Shuai ^a ,
Shan Lianhai ^a ,
Gao Feng ^a ,
Zhou Xianli ^a,b,,

a.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
b.
School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031
c.
School of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002

Corresponding author: Zhou Xianli, zhouxl@swjtu.edu.cn
Received Date: 16 February 2017
Revised Date: 9 March 2017
Available Online: 1 July 2017
Fund Project: the Research Foundation for Educational Commission of Sichuan Province 15ZB0140the Fundamental Research Funds for Central Universities 2682017QY04the National Natural Science Foundation of China 81402803Project supported by the National Natural Science Foundation of China (No. 81402803), the Small Molecule Natural Medicine Innovation Team (No. 15TD0048), the Research Foundation for Educational Commission of Sichuan Province (No. 15ZB0140) and the Fundamental Research Funds for Central Universities (No. 2682017QY04)the Small Molecule Natural Medicine Innovation Team 15TD0048

Figures(3)

A new C₁₈ diterpenoid alkaloid, leucostonine (1), was isolated from the whole plant of Aconitum leucostomum Vorosch., together with twelve known diterpenoid alkaloids. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HR-ESI-MS, 1D NMR and 2D NMR spectra. 12 compounds were tested for their antifeedant activity against larvae of Spodoptera exigua Hiibner. Anthranoyllycoctonine and avadharidine showed considerable potent antifeedant activity (EC₅₀ < 1 mg/cm²), followed by N-acetylsepaconitine, finaconitine and N-deacetylappaconitine (EC₅₀ < 2 mg/cm²).
- aconitum,
- Aconitum leucostomum,
- diterpenoid alkaloid,
- leucostonine,
- antifeedant activity
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