Citation: Cheng Hua, Nie Ren, Wang Wanqiang, Huang Lin, Liu Ke, Chen Cheng, Wu Qiongyou. Research Progress in Structural Modification of Antimycin A[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1368-1381. doi: 10.6023/cjoc201702010 shu

Research Progress in Structural Modification of Antimycin A

Cheng Hua ^a ,
Nie Ren ^a ,
Wang Wanqiang ^a ,
Huang Lin ^a ,
Liu Ke ^a ,
Chen Cheng ^c,*,, ,
Wu Qiongyou ^b,*,,

a.
Department of Chemical Engineering and Food Science, Hubei Universtry of Arts and Science, Xiangyang 441053
b.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079
c.
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070

Corresponding author: Chen Cheng, chengchen@whut.edu.cn Wu Qiongyou, qywu@mail.ccnu.edu.cn
Received Date: 9 February 2017
Revised Date: 3 March 2017

Fund Project: the Hubei Provincial Department of Education Q20102606the National Natural Science Foundation of China 21472063the National Natural Science Foundation of China 21502062the Xiangyang Science and Technology Bureau 2010GG1B33the Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices HLOM151005

Figures(18)

Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Q_i site of the cytochrome bc₁ complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.
- antimycin A,
- inhibitor,
- biological activity,
- structural modification
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