Citation: Shi Yujun, Ye Linyu, Zhong Sulin, Cao Xiongfei, Dai Hong, Hong Yu, Li Chunjian, Shi Jian, Wu Jinming. Synthesis and Insecticidal Activities of Novel Pyrazole Amides Containing 1, 3, 4-Oxadiazole Moiety[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1844-1849. doi: 10.6023/cjoc201702006 shu

Synthesis and Insecticidal Activities of Novel Pyrazole Amides Containing 1, 3, 4-Oxadiazole Moiety

Shi Yujun ^a ,
Ye Linyu ^a ,
Zhong Sulin ^b ,
Cao Xiongfei ^b ,
Dai Hong ^a,, ,
Hong Yu ^a ,
Li Chunjian ^c ,
Shi Jian ^c ,
Wu Jinming ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
United Nations Nantong Pesticide Forulation Development Centre, Nantong 226006
c.
Analysis and Testing Center, Nantong University, Nantong 226019

Corresponding author: Dai Hong, aihong_2015@aliyun.com Wu Jinming, ntgao2016@163.com
Received Date: 7 February 2017
Revised Date: 7 March 2017
Available Online: 17 July 2017
Fund Project: the Science and Technology Project Fund of Nantong City MS22015020Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201610304047Z) and the Science and Technology Innovation Foundation for the Graduate Students of Nantong University (No. YKC16086)the National Natural Science Foundation of China 21372135the Science and Technology Innovation Foundation for the College Students of Jiangsu Province 201610304047Zthe Science and Technology Innovation Foundation for the Graduate Students of Nantong University YKC16086the Research Foundation of the Six People Peak of Jiangsu Province 2013-SWYY-013

Figures(2)

In order to find new pesticide with potent bioactivities, a series of novel pyrazole amides carrying 1, 3, 4-oxadiazole moiety were prepared according to the structure of tebufenpyrad. The structures of the title compounds were characterized by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data showed that some target compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, five compounds had insecticidal activity against Oriental armyworm with 80%~100%, and four compounds displayed comparable insecticidal activity against Oriental armyworm to that of the control tolfenpyrad. In addition, 1-methyl-3-ethyl-4-chloro-N-{[5-(4-methylphenyl)-1, 3, 4-oxadiazol-2-yl)methyl]-1H-pyrazole-5-carboxamide (9g) exhibited 100% insecticidal activity against Aphis medicaginis at 500 μg/mL.
- 1, 3, 4-oxadiazole,
- pyrazole,
- synthesis,
- insecticidal activity
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