Citation: Shi Dongdong, Bao Hanyang, Xu Zheng, Liu Yunkui. Synthesis of 6-Aryl Phenanthridines via Iron-Catalyzed sp²-C-H Bond Amination/Aromatization Reaction[J]. Chinese Journal of Organic Chemistry, ;2017, 37(5): 1290-1294. doi: 10.6023/cjoc201701054 shu

Synthesis of 6-Aryl Phenanthridines via Iron-Catalyzed sp²-C-H Bond Amination/Aromatization Reaction

State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Liu Yunkui, ykuiliu@zjut.edu.cn
Received Date: 30 January 2017
Revised Date: 27 March 2017

Fund Project: Project supported by the National Natural Science Foundation of China 21372201the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology, and the Xin Miao Talents Program of Zhejiang Province 2016R403057Project supported by the National Natural Science Foundation of China 21172197

Figures(1)

With FeCl₂ as a catalyst and Selectfluor as an oxidant, an efficient and highly selective synthesis of 6-aryl phenanthridines in one-pot manner has been achieved via an intramolecular sp²-C-H bond amination/aromatization of N-(biphenyl-2-yl(aryl)methyl)benzenesulfonamide derivatives. The optimized reaction conditions were established through systematic investigations of solvents, temperature, catalysts, oxidants and their dosages in the reaction. The present reaction has advantages of simple operation, easy availability of starting materials, the use of inexpensive and low-toxic iron catalyst, and good compatibility of substrates.
- iron catalysis,
- C-H activation,
- amination,
- phenanthridines
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Synthesis of 6-Aryl Phenanthridines via Iron-Catalyzed sp2-C-H Bond Amination/Aromatization Reaction

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通讯作者: 陈斌, bchen63@163.com

Synthesis of 6-Aryl Phenanthridines via Iron-Catalyzed sp²-C-H Bond Amination/Aromatization Reaction