Citation: Yu Le, Liu Ruijuan, Li Ming. Tetrabutylammonium Iodide/t-Butylhydroperoxide Catalytic/Oxidative Synthesis of Thiazolylidene Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1800-1807. doi: 10.6023/cjoc201701045 shu

Tetrabutylammonium Iodide/t-Butylhydroperoxide Catalytic/Oxidative Synthesis of Thiazolylidene Derivatives

State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042

Corresponding author: Li Ming, wenlirong@qust.edu.cn
Received Date: 22 January 2017
Revised Date: 5 March 2017
Available Online: 8 July 2017
Fund Project: the National Natural Science Foundation of China 21372137Project supported by the National Natural Science Foundation of China (No. 21372137)

Figures(6)

A novel method based on reaction of β-ketothioamides (KTAs) with malononitrile to construct thiazolylidenes has been developed under metal-free conditions. This method used cheap tetrabutylammonium iodide (TBAI) as catalyst and t-butylhydroperoxide (TBHP) as oxidant in the presence of Et₃N at room temperature for 1 h to synthesize a series of 4-aminothiazolylidene derivatives in good yields. This reaction has some advantages such as simple operation, mild reaction conditions, short reaction time, environmentally benign and simple work-up.
- thiazolylidenes,
- β-ketothioamides,
- TBAI/TBHP,
- catalysis
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