Citation: Zan Ningning, Wan Fuxian, Wang Shichun, Zhang Junhui, Jiang Lin. Synthesis and Biological Activity of Novel 3-Phenylpropan-1-one Oxime Ethers Containing Pyridine Moiety[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1537-1541. doi: 10.6023/cjoc201701009 shu

Synthesis and Biological Activity of Novel 3-Phenylpropan-1-one Oxime Ethers Containing Pyridine Moiety

College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018

Corresponding author: Jiang Lin, jiangl@sdau.edu.cn
Received Date: 4 January 2017
Revised Date: 12 February 2017

Fund Project: the Natural Science Foundation of Shandong Province ZR2014BM030

Figures(1)

To search for the pyridine pesticide lead compound with high antigungal activity, a series of novel 3-phenyl propan-1-one oxime ethers bearing pyridine moiety were synthesized using 3-acetypyridine, benzaldehyde, substituted anilines and alkoxyamine hydrochlorides as starting materials. The structures of target compounds were determined by IR, ¹H NMR, ¹³C NMR and elemental analysis. Meanwhile, the target compounds were evaluated for their antifungal activities against S. sclerotiorum and B. cinerea by the mycelium growth rate method. The results indicated that some compounds displayed high antifungal activity to the two kinds of pathogenic fungi, and their activities were even higher than that of the positive control, chlorothalonil.
- heterocycles,
- pyridine,
- ketones,
- oxime ethers,
- biological activitity
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