Citation: Wang Kehu, Wang Yalin, Yin Xuejiao, Peng Xiansha, Huang Danfeng, Su Yingpeng, Hu Yulai. Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines[J]. Chinese Journal of Organic Chemistry, ;2017, 37(7): 1764-1773. doi: 10.6023/cjoc201612042 shu

Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Wang Kehu, wangkh@nwnu.edu.cn Hu Yulai, huyl@nwnu.edu.cn
Received Date: 13 December 2016
Revised Date: 1 March 2017
Available Online: 14 July 2017
Fund Project: National Natural Science Foundation of China 21262031National Natural Science Foundation of China 21462037Project supported by the National Natural Science Foundation of China (Nos. 21262031, 21462037)

A series of trifluoromethylated homoallylic N-acylhydrazines were obtained from one-pot reaction of aryl trifluoroketones, acylhydrazines and allyl bromide promoted by tin powder in the presence of boron trifluoride diethyl etherate (BF₃·OEt₂). The features of this process include good yields, wide substrate scope, mild conditions and easy operation. Trifluoromethylated homoallylic N-acylhydrazines are useful trifluoromethyl building blocks. They can be easily transformed into trifluoromethylated nitrogen-containing compounds.
- one-pot,
- tin powder,
- aryl trifluoroketones,
- trifluoromethylated homoallylic N-acylhydrazines
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