Citation: Ma Jimei, Xie Lingyun, Wang Longwen, Chen Hangwei, Zeng Zhen, Chen Hao, Jiang Hong. Synthesis and α-Glycosidase Inhibitory Activity of Three Ascorbic Acid Glycosides[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1426-1432. doi: 10.6023/cjoc201612037 shu

Synthesis and α-Glycosidase Inhibitory Activity of Three Ascorbic Acid Glycosides

Department of Chemistry, College of Science, Huazhong Agricultural University, Wuhan 430070

Corresponding author: Ma Jimei, majimei@mail.hzau.edu.cn Jiang Hong, jianghong@mail.hzau.edu.cn
Received Date: 11 December 2016
Revised Date: 20 January 2017

Fund Project: the National Natural Science Foundation of China 21402056the Fundamental Research Funds for the Central Universities 2014QC007

Figures(5)

2-O-(β-D-Glucopyranosyl)-L-ascorbic acid, a natural β-glycoside with ascorbic acid moiety present in Lycium barbarum, and its two analogues were chemically synthesized. Their inhibitory effect on yeast α-glucosidase and α-amylase were investigated with commercially available acarbose as positive control. The biological assays demonstrated the distinct inhibitory effect of these compounds on α-glucosidase activity and weak inhibitory activity against pancreatic α-amylase. The kinetic study indicated that these compounds were competitive inhibitors. These results imply that these three β-glycosides have the potential to be developed as α-glucosidase inhibitors.
- 2-O-(β-D-glucopyranosyl)-L-ascorbic acid,
- analogue,
- synthesis,
- α-glucosidase,
- α-amylase,
- inhibitor
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