Citation: Wu Lili, Su Yingpeng, Chong Siying, Zhang Weigang, Huang Danfeng, Wang Kehu, Hu Yulai. Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF₃ Group from 2, 2, 2-Trifluoroacetophenone Substrates[J]. Chinese Journal of Organic Chemistry, ;2017, 37(4): 936-942. doi: 10.6023/cjoc201612006 shu

Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF₃ Group from 2, 2, 2-Trifluoroacetophenone Substrates

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Su Yingpeng, suyp51@nwnu.edu.cn Hu Yulai, huyl@nwnu.edu.cn
Received Date: 2 December 2016
Revised Date: 4 January 2017

Fund Project: the National Natural Science Foundation of China 21362033the National Natural Science Foundation of China 21262031

Figures(1)

An asymmetric Henry reaction with 2, 2, 2-trifluoroacetophenone as trifluoromethyl building block was described. This reaction was catalyzed by bifunctional thiourea derived from quinine to give the product bearing a CF₃ stereogenic center in good yield with good enantioselectivity.
- organocatalyst,
- chiral thiouera,
- Henry reaction,
- 2, 2, 2-trifluoroacetophenone
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沈阳化工大学材料科学与工程学院沈阳 110142

Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF3 Group from 2, 2, 2-Trifluoroacetophenone Substrates

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通讯作者: 陈斌, bchen63@163.com

Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF₃ Group from 2, 2, 2-Trifluoroacetophenone Substrates