Citation: Zhou Ting, Wang Daolin, Qian Jianhua, Zhao Wei. Iodine Promoted Synthesis of Pyrano[3, 2-c]quinoline-4, 5-diones[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1548-1555. doi: 10.6023/cjoc201612001 shu

Iodine Promoted Synthesis of Pyrano[3, 2-c]quinoline-4, 5-diones

Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry andChemical Engineering, Bohai University, Jinzhou 121003

Corresponding author: Wang Daolin, wangdaolin@sina.com
Received Date: 1 December 2016
Revised Date: 11 January 2017

Fund Project: the Innovation Team Project of Liaoning Province Education Department 2015001

Figures(2)

An efficient method for the synthesis of pyrano[3, 2-c]quinoline-4, 5-dione derivatives via iodine promoted intramolecular cyclization of 1-methyl-3-cinnamoyl-4-hydroxyquinolin-2-one, synthesized from aldol condensation of 1-methyl-3-acetyl-4-hydroxyquinolin-2-one with aromatic aldehydes in the presence of pyridine and PEG-400 under ultrasound irradiation, has been described. This method offers the advantages of a green approach, easy work-up, mild conditions and good yields.
- quinoline,
- heterocycle,
- ultrasound irradiation,
- iodine,
- synthesis
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