Citation: Zhang Zipeng, Yang Xinying, Fang Hao. Synthesis and Antiproliferative Activity of Novel Purin-8-one Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1479-1486. doi: 10.6023/cjoc201611031 shu

Synthesis and Antiproliferative Activity of Novel Purin-8-one Derivatives

School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012

Corresponding author: Fang Hao, haofangcn@sdu.edu.cn
Received Date: 23 November 2016
Revised Date: 3 January 2017

Fund Project: the National Natural Science Foundation of China No. 21672127

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A series of novel purin-8-one derivatives were prepared with the starting materials of 2, 4-dichloro-5-nitropyrimidine and followed by multi-step reactions. The structures of all target compounds were identified by ¹H NMR, ¹³C NMR and HRMS. The preliminary biological evaluations were performed using thiazolyl blue tetrazolium bromide (MTT) method to test their antiproliferative activities against some tumor cell lines. The results suggested that some compounds exhibited good anti-proliferative activities against tumor cell lines. Especially, four compounds showed similar or better inhibitory activities against Hela, MOLT-4 and K562 tumor cell lines compared with R-roscovitine.
- purine derivatives,
- antitumor,
- synthesis
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