Citation: Li Jun, Yang Tianyu, Zhang Huaiyuan, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai. One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder[J]. Chinese Journal of Organic Chemistry, ;2017, 37(4): 925-935. doi: 10.6023/cjoc201611009 shu

One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Huang Danfeng, huyl@nwnu.edu.cn Hu Yulai, huangdf@nwnu.edu.cn
Received Date: 4 November 2016
Revised Date: 26 December 2016

Fund Project: Project supported by the National Natural Science Foundation of China 21262031Project supported by the National Natural Science Foundation of China 21462037

Figures(1)

An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and allyl bromide promoted by indium powder is reported, and a series of trifluoromethylated homoallylic N-acylhydrazines were obtained with good to excellent yields. The features of this process include readily available starting materials as trifluoromethyl building blocks, mild conditions and easy operation.
- one-pot,
- indium powder,
- trifluoroacetaldehyde methyl hemiacetal,
- trifluoroketones,
- arylacylhydrazines,
- trifluoromethylated homoallylic N-acylhydrazines
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