Citation: Fu Wenqiang, Tan Ping, Deng Wei, Xiang Jiannan. Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1501-1505. doi: 10.6023/cjoc201610031 shu

Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid

Fu Wenqiang ^a ,
Tan Ping ^b ,
Deng Wei ^a ,
Xiang Jiannan ^a,*,,

a.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082
b.
Hunan Mechanical and Electrical Polytechnic, Changsha 410151

Corresponding author: Xiang Jiannan, jnxiang@hnu.edu.cn
Received Date: 18 October 2016
Revised Date: 30 December 2016

Fund Project: the Planned Science and Technology Project of Hunan Province 2015WK3003the Scientific Research Fund of Hunan Provincial Education Department 14C0405

Figures(1)

The haloalkynes were hydrolyzed to α-haloketones by sulfuric acid promotion in ionic liquids (ILs) with 85%~94% yields. The ILs-H₂SO₄ reaction system could be easily recycled (more five times) without any effect for reaction yield. At the same time, a wide scope of substrates haloalkynes were proper in this reaction system and a series of α-chloro/bromo/iodo acetophenones with different substituent (such as methyl, methoxyl, hydroxyl, nitro etc.) and aliphatic α-haloketones have been obtained in good yields.
- ionic liquid,
- haloalkynes,
- hydration,
- α-haloketones,
- recyclable
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