Citation: Zhang Jie, Du Guangfen, Gu Chengzhi, Dai Bin. Strecker Reaction of Ethyl Cyanoformate with Aldimines Catalyzed by N-Heterocyclic Carbene[J]. Chinese Journal of Organic Chemistry, ;2017, 37(4): 914-919. doi: 10.6023/cjoc201610029 shu

Strecker Reaction of Ethyl Cyanoformate with Aldimines Catalyzed by N-Heterocyclic Carbene

Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003

Corresponding author: Gu Chengzhi, gcz_tea@shzu.edu.cn
Received Date: 17 October 2016
Revised Date: 4 January 2017

Fund Project: Project supported by the National Natural Science Foundation of China 21262027

The Strecker reaction of ethyl cyanoformate with aldimines was carried out with N-heterocyclic carbene (NHC) as the catalyst. The reaction conditions were optimized with different catalysts, catalyst loading and various solvents. 14 α-aminonitriles were synthesized via the optimal reaction conditions. It was found that both aromatic and aliphatic aldimines were suitable electrophiles and the highest yield was 93%. The reaction has the virtue of simple operation, mild reaction condition, high yield and environment friendliness.
- N-heterocyclic carbenes,
- Strecker reaction,
- imines,
- ethyl cyanoformate
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