Citation: An Yanni, Li Jianxiao, Li Meng, Li Chunsheng, Yang Shaorong. N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1, 2-a]pyridines with Disulfides[J]. Chinese Journal of Organic Chemistry, ;2017, 37(3): 720-725. doi: 10.6023/cjoc201609033 shu

N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1, 2-a]pyridines with Disulfides

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640

Corresponding author: Yang Shaorong, lisryang@scut.edu.cn
Received Date: 29 September 2016
Revised Date: 7 November 2016

Fund Project: the China Postdoctoral Science Foundation 2016T90779the National Natural Science Foundation of China 21502055the Fundamental Research Funds for the Central Universities 2015ZM150the China Postdoctoral Science Foundation 2015M572303

An efficient and practical N-iodosuccinimide-promoted regioselective arylsulfenylation of imidazo[1, 2-a]pyridines with disulfides has been developed to afford functionalized 3-sulfenylimidazo[1, 2-a]pyridines heterocycles in moderate to good yields. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR and HRMS. Furthermore, this method has the advantages of mild reaction conditions, broad substrates scope and environmentally benign. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.
- N-iodosuccinimide,
- ionic liquids,
- imidazo[1, 2-a]pyridines,
- disulfides,
- arylsulfenylation
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