Citation: Wang Dong, Wang Daolin, Qian Jianhua. An Efficient Synthesis of Benzothieno-[3', 2': 2, 3]pyrido[4, 5-d]thiazolo[3, 2-a]pyrimidin-5-ones[J]. Chinese Journal of Organic Chemistry, ;2017, 37(3): 698-703. doi: 10.6023/cjoc201609031 shu

An Efficient Synthesis of Benzothieno-[3', 2': 2, 3]pyrido[4, 5-d]thiazolo[3, 2-a]pyrimidin-5-ones

Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering, Bohai University, Jinzhou 121003

Corresponding author: Wang Daolin, wangdaolin@sina.com
Received Date: 29 September 2016
Revised Date: 7 November 2016

Fund Project: the Innovation Team Project of Liaoning Province Education Department 2015001

Figures(2)

A series of novel benzothieno[3', 2':2, 3]pyrido[4, 5-d]thiazolo[3, 2-a]pyrimidinone derivatives are prepared via sulfamic acid-catalyzed Pictet-Spengler cyclization of 7-(3-amino-5-phenylaminothiazolo-2-yl) thiazolo[3, 2-a]pyrimidin-5-one, which in turn were obtained from the Thorpe-Ziegler isomerization of 7-(chloromethyl) thiazolo[3, 2-a]pyrimidin-5-one with 2-mercaptobenzonitrile. The method was characterized with raw material easy to get, mild reaction conditions, good yields and a facile and efficient synthetic method of novel fused pyrimidines.
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