Citation: Zhang Meimei, Wang Jie, Liu Jianquan, Wang Xiangshan. One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions[J]. Chinese Journal of Organic Chemistry, ;2017, 37(6): 1565-1570. doi: 10.6023/cjoc201608020 shu

One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions

a.
School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116
b.
Kewen College, Jiangsu Normal University, Xuzhou 221116

Corresponding author: Wang Xiangshan, xswang@jsnu.edu.cn
Received Date: 24 August 2016
Revised Date: 24 December 2016

Fund Project: the Natural Science Foundation of Jiangsu Normal University 15XLA05the Major Basic Natural Science Foundation of University in Jiangsu Province 14KJA150004

Figures(4)

A series of 11-aryl-8, 11-dihydrofuro[3', 4':5, 6]pyrido[3, 2-f]quinoxalin-10(7H)-one derivatives were obtained via a one-pot and three-component reaction of aromatic aldehydes, 6-aminoquinoxaline and tetronic acid in EtOH. The structure of 11-(4-nitrophenyl)-8, 11-dihydrofuro[3', 4':5, 6]pyrido[3, 2-f]quinoxalin-10(7H)-one (4g) was confirmed by X-ray diffraction analysis. This procedure had the advantages of operation simplicity, catalyst-free and without isolating intermediates, and provided a good method for the synthesis of fused tetracyclic heterocycles containing furan, pyridine and quinoxaline moieties at the same time.
- furopyridoquinoxaline,
- 6-aminoquinoxaline,
- three-component reaction,
- crystal structure,
- synthesis
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