Citation: He Ping, Tang Lijun, Zhong Keli, Hou Shuhua, Yan Xiaomei. Fluorescence Recognition of H₂S by a Benzothiazole Derivative and Its Live Cell Imaging[J]. Chinese Journal of Organic Chemistry, ;2017, 37(2): 423-428. doi: 10.6023/cjoc201608003 shu

Fluorescence Recognition of H₂S by a Benzothiazole Derivative and Its Live Cell Imaging

He Ping ^a ,
Tang Lijun ^a,*,, ,
Zhong Keli ^a ,
Hou Shuhua ^a ,
Yan Xiaomei ^b,*,,

a.
College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013
b.
College of Laboratory Medicine, Dalian Medical University, Dalian 116044

Corresponding author: Tang Lijun, ljtang@bhu.edu.cn Yan Xiaomei, xmyan1978@sina.com
Received Date: 4 August 2016
Revised Date: 19 September 2016

Fund Project: the National Natural Science Foundation of China U1608222the Liaoning Excellent Talents in University LR2015001the National Natural Science Foundation of China 21476029

Figures(10)

A new benzothiazole-derived fluorescence probe 2-(4-azidobenzyl) oxy-3-(benzo[d]thiazol-2-yl)-5-methylben-zaldehyde (HBTA) was synthesized from 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde, and the structure of HBTA was characterized. The recognition behaviors of HBTA to H₂S were investigated and the results show that HBTA exhibits good selectivity and sensitivity to H₂S with fast response and good anti-interference ability. The probe can be applied to detect H₂S in a broad pH range, and the detection limit of HBTA for H₂S was estimated to be 9.09×10^-7 mol·L^-1. Cell imaging studies reveal that HBTA is capable of detect H₂S in live cells.
- hydrogen sulfide,
- fluorescent probe,
- benzothiazole,
- cells imaging
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Fluorescence Recognition of H₂S by a Benzothiazole Derivative and Its Live Cell Imaging