Citation: Lu Xinwei, Xie Ying, Wang Jing, Tan Lei, Zhan Yan, Ruan Jia, Xu Chaoqun. Two New Compounds from the Leaves of Paliurus ramosissimus[J]. Chinese Journal of Organic Chemistry, ;2017, 37(2): 520-525. doi: 10.6023/cjoc201607044 shu

Two New Compounds from the Leaves of Paliurus ramosissimus

Lu Xinwei ^a,b ,
Xie Ying ^a,b ,
Wang Jing ^a,b ,
Tan Lei ^b ,
Zhan Yan ^b ,
Ruan Jia ^b ,
Xu Chaoqun ^b,*,,

a.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075
b.
Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041

Corresponding author: Xu Chaoqun, chaoqun_xu@sina.com
Received Date: 29 July 2016
Revised Date: 22 September 2016

Fund Project: the National Key Technology Research and Development Program of the Science and Technology Department of Sichuan Province 15ZC1978the Sichuan Provincial Research Institute of Science and Technology Achievements Transformation Fund 14010139

Figures(3)

To study chemical constituents in the ethanol extract of Paliurus ramosissimus (Lour.) Poir, two new compounds along with four known compounds were isolated and purified by repeated gel column chromatographies and high performance preparative liquid chromatography. On the basis of spectroscopic methods (HR-ESIMS, 1D-and 2D-NMR), their structures were identified as 2α-(cis-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(trans-p-hydroxy-cinnamyloxy) betulinic acid (1), 2α-(trans-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(cis-p-hydroxy-cinnamyloxy) betulinic acid (2), messagenic acid A (3), mes-sagenic acid B (4), betulinaldehyde (5) and β-sitosterol (6). Among them, compounds 1 and 2 were new compounds named as paliurusene A and paliurusene B, which belong to triterpenoids, compounds 3~6 were isolated from this plant for the first time. The anti-tumor activity of compounds 1~3 was evaluated by methyl thiazolyl tetrazolium (MTT) assays. The result showed that compounds 1~3 presented obvious cytotoxicity in vitro against the cancer cell lines.
- Paliurus ramosissimus (Lour.) Poir.,
- pentacyclic triterpenoids,
- paliurusene A,
- paliurusene B,
- anti-tumor
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