Citation: Ren Yaping, Liu Xu, Wang Rui, Zhou Yuanqing, Li Biao, Xu Yan, Song Maoping. Synthesis and Properties of 4-Ferrocenyl-benzoyl-thiadiazole Derivatives[J]. Chinese Journal of Organic Chemistry, ;2017, 37(1): 110-115. doi: 10.6023/cjoc201607008 shu

Synthesis and Properties of 4-Ferrocenyl-benzoyl-thiadiazole Derivatives

Ren Yaping ^a ,
Liu Xu ^a ,
Wang Rui ^b ,
Zhou Yuanqing ^a ,
Li Biao ^a ,
Xu Yan ^a,*,, ,
Song Maoping ^a

a.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
b.
Dingzhou Yingcai Middle School, Dingzhou 073000

Corresponding author: Xu Yan, xuyan@zzu.edu.cn
Received Date: 5 July 2016
Revised Date: 6 September 2016

Fund Project: the National Natural Science Foundation of China 21171149

Figures(4)

Seven kinds of ferrocenyl-benzoyl-thiadiazole compounds FcL₁~FcL₇ were synthesized by using 4-ferrocenyl-benzoic and 2-amino-5-aryl-1, 3, 4-thiadiazole as raw materials. These compounds were characterized by IR, ¹H NMR and elemental analysis. The crystal structure of FcL₄ was determined by X-ray diffraction analysis. The electrochemical research showed that the redox reaction on the surface of electrode was reversible with single electron, and FcL₁~FcL₇ have a certain redox response to Pb²⁺and Zn²⁺. The antibacterial activity tests indicated that FcL₁~FcL₇ presented significant activity and selectivity against Fusarium graminearum. FcL₅~FcL₇ exhibited good inhibition against human esophageal cancer cells in the anticancer activity tests.
- ferrocene,
- thiadiazole,
- crystal structure,
- electrochemistry,
- biological activity
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